When treating hypothyroidism in dogs, it is important to set realistic time frames for resolution of clinical signs. As a rough guide, clinical signs should respond within the following timelines with appropriate treatment:

• Mentation and activity = 2-7 days
• Lipaemia and other clinical pathologic changes = 2-4 days
• Dermatologic abnormalities = 2-4 months
• Neurological abnormalities = 1-3 months
• Cardiac abnormalities = 1-2 months
• Reproductive abnormalities  = 3-10 months